Pakistan Karachi bomb blast kills at least 25
The blast in the mainly Shia Muslim area of Abbas town destroyed several buildings and set others on fire. Some reports spoke of a second explosion.
Rescuers have been struggling to reach people thought to be trapped under the rubble.
Pakistan’s Shia minority are the target of frequent sectarian attacks from Sunni militant groups.
The explosion sent a huge column of smoke into the sky above Karachi and caused a power cut in part of the city.
Residents have been using car headlights to help rescuers search for survivors, local media reports said.
More than 50 people were injured, and there are fears the number of dead will rise.
Pakistan’s main political and religious leaders rushed to condemn the attack – the latest to target the Shia minority.
Last month nearly 90 people were killed in a bomb attack on a Shia area in the south western city of Quetta.
Some relatives of the victims there initially refused to bury their dead in protest at what they said was the failure of the authorities to protect their community from attack.